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陈怡环1-s2.0-S0091305715300290-main

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Quetiapine and repetitive transcranial magnetic stimulation ameliorate depression-like behaviors and up-regulate the proliferation of hippocampal-derived neural stem cells in a rat model of depression: The involvement of the BDNF/ERK signal pathway Yi-huan Chen a,1 , Rui-guo Zhang a,1 ,FenXue a,1 , Hua-ning Wang a , Yun-chun Chen a , Guang-tao Hu b ,YePeng c , Zheng-wu Peng a, ⁎, Qing-rong Tan a, ⁎ a Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China b Mental Health Center, 324 Hospital of PLA, Chongqing 400041, China c Air Force General Hospital of PLA, Beijing, China abstractarticle info Article history: Received 25 May 2015 Received in revised form 7 July 2015 Accepted 9 July 2015 Available online 12 July 2015 Keywords: Quetiapine rTMS CUS NSCs BDNF/ERK Quetiapine (QUE) and repetitive transcranial magnetic stimulation (rTMS) have been considered to be possible monotherapies for depression or adjunctive therapies for the treatment of the resistant depression, but the un- derlying mechanisms remain unclear. The present study aimed to assess the effects of combined QUE and rTMS treatment on depressive-like behaviors, hippocampal proliferation, and thein vivoandin vitroexpressions of phosphorylated extracellular signal-regulated protein kinase (pERK1/2) and brain-derived neurotrophic factor (BDNF) in male Sprague–Dawley rats. The administration of QUE and rTMS was determined not only to reverse the depressive-like behaviors of rats exposed to chronic unpredictable stress (CUS) but also to restore the protein expressions of pERK1/2 and BDNF and cell proliferation in the hippocampus. Additionally, QUE and rTMS pro- moted the proliferation and increased the expression of pERK1/2 and BDNF in hippocampal-derived neural stem cells (NSCs), and these effects were abolished by U0126. Taken together, these results suggest that the antidepressive-like effects of QUE and rTMS might be related to the activation of the BDNF/ERK signa
陈怡环1-s2.0-S0091305715300290-main
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