外2013 肖农【IF 1.253 Journal of Clinical Neuroscience】1Hz rTMS可以有效改善TS患儿临床症状至少6个月 CCY-I

Clinical Study Transcranial magnetic stimulation at 1 Hertz improves clinical symptoms in children with Tourette syndrome for at least 6 months Kai Le, Ling Liu, Manli Sun, Ling Hu, Nong Xiao ⇑ Ministry of Education Key Laboratory of Child Development and Disorders, and Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders, and Rehabilitation Centre, Children’s Hospital, Chongqing Medical University, NO. 136 Zhongshan2nd Road, Yuzhong District, Chongqing 400014, China article info Article history: Received 2 November 2011 Accepted 3 January 2012 Keywords: Children Repetitive transcranial magnetic stimulation (rTMS) Supplementary motor area (SMA) Tourette Syndrome (TS) abstract Tourette syndrome (TS) is characterized by multiple motor and phonic tics. Repetitive transcranial mag- netic stimulation (rTMS) targeting the supplemental motor area (SMA) can reduce tic severity. Here, we investigated whether 1 Hz rTMS targeted to the SMA could improve symptoms in children with TS. Twenty-five children with TS (aged under 16 years) received 20 daily sessions of rTMS to the SMA at a frequency of 1 Hz, 110% of resting motor threshold (RMT). Clinical assessment and physiological mea- sures of the left and right RMT were conducted at different times during treatment and follow-up. After four weeks of treatment we observed statistically significant reductions on the Yale Global Tic Severity Scale, Clinical Global Impression Scale, Swanson, Nolan and Pelham Rating Scale, version IV for atten- tion-deficit hyperactivity disorder, Children’s Depression Inventory, Spence Children’s Anxiety Scale and a novel Attention Test. In addition, symptom improvement correlated with an increase of both right and left RMT and was stable at six months follow-up. Therefore, we found that 1 Hz rTMS to the SMA can improve clinical symptoms in children with TS for at least six months. ⇑2012 Elsevier Ltd. All rights reserved. 1. Introduction